Company Filing History:

14 out of 576

The Salk Institute for Biological Studies

patents

2 out of 512

Sloan-kettering Institute for Cancer Research

patents

1 out of 832,680

Other

patents

where one patent can have more than one assignee

Years Active: 1991-2007

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16 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 7189510 - Response element compositions and assays employing same (2007-03-13),

2. 7038022 - Multimeric forms of members of the steroid/thyroid superfamily of receptors (2006-05-02),

3. 7033828 - Nucleic acid encoding gamma retinoic acid receptor fusion protein (2006-04-25),

4. 6492137 - Response element compositions and assays employing same (2002-12-10),

5. 6458926 - Heterodimer complex of RXR and NURR1 or NGFI-B (2002-10-01),

6. 6391847 - Method, polypeptides, nucleotide sequence of XOR-6, a vitamin D-like receptor from xenopus (2002-05-21),

7. 6284870 - Gamma retinoic acid receptor (2001-09-04),

8. 5707800 - Retinoic acid response elements and assays employing same (1998-01-13),

9. 5599904 - Chimeric steroid hormone superfamily receptor proteins (1997-02-04),

10. 5597693 - Hormone response element compositions and assay (1997-01-28),

11. 5571692 - Retinoic acid receptor .alpha., vectors and cells comprising the same (1996-11-05),

12. 5548063 - Retinoic acid receptor alpha proteins (1996-08-20),

13. 5530094 - Gamma retinoic acid receptor (1996-06-25),

14. 5274077 - Retinoic acid receptor composition (1993-12-28),

15. 5260432 - Human gamma retinoic acid receptor DNA (1993-11-09),

Title: Kazuhiko Umesono: Innovator in Molecular Biology

Introduction

Kazuhiko Umesono is a prominent inventor based in La Jolla, California, known for his significant contributions to molecular biology. He holds a total of 16 patents, showcasing his innovative work in the field. His research has led to advancements in understanding the interactions of steroid and thyroid hormone receptors.

Latest Patents

Umesono's latest patents include groundbreaking discoveries related to response element compositions and assays. These DNA segments have been characterized by their sequences, which serve as response elements that confer responsiveness to ligands for several members of the steroid/thyroid superfamily of receptors. This innovation allows for the transcriptional activation and repression of promoters in cells. By utilizing transcriptional control regions that comprise these response elements in combination with functional promoters, Umesono has enabled the creation of recombinant DNA vectors. These vectors contain genes whose transcription and expression are regulated by ligands for members of the steroid/thyroid superfamily of receptors. Additionally, he has discovered that various members of this superfamily can interact to form multimeric species, which modulate the transcriptional activity of genes under hormone expression control.

Career Highlights

Throughout his career, Umesono has worked at prestigious institutions, including the Salk Institute for Biological Studies and the Sloan Kettering Institute for Cancer Research. His work has significantly impacted the understanding of gene regulation and receptor interactions.

Collaborations

Umesono has collaborated with notable scientists, including Ronald Mark Evans and Estelita S. Ong. These collaborations have further enriched his research and contributed to advancements in molecular biology.

Conclusion

Kazuhiko Umesono's innovative work in molecular biology has led to significant advancements in understanding hormone receptor interactions and gene regulation. His contributions continue to influence the field and inspire future research.

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