Location History:
- Yokohama, JP (1988)
- Mobara, JP (1989 - 1997)
Company Filing History:
3 out of 1,037 
2 out of 348 
1 out of 4 Years Active: 1988-1997
Title: **Kazuaki Manabe: A Pioneer in Recombinant DNA Technology**
Introduction
Kazuaki Manabe, an esteemed inventor based in Mobara, Japan, has made significant contributions to the field of biotechnology, particularly in the development of recombinant DNA technology. With a total of three patents, his work has laid the foundation for advancements in microbial protein production.
Latest Patents
Kazuaki Manabe's latest patents are a testament to his innovative approach. One of his notable inventions focuses on a DNA base sequence containing regions involved in the production of neutral protease. This invention includes a neutral protease gene of Bacillus amyloliquefaciens, encapsulating various crucial regions necessary for gene expression and protein secretion. This design enables the extracellular production of neutral protease in substantial quantities by culturing B. subtilis transformed with a recombinant DNA comprising pUB110 and the neutral protease gene.
Another important patent involves a DNA base sequence capable of enhancing the amount of protein secreted by microorganisms. This invention encompasses a recombinant plasmid and outlines a method for preparing the plasmid. This method allows for the efficient selection of suitable transformants during the cloning process by measuring the protein secretion levels and the enzyme activity. Moreover, it introduces a microbial breeding technique to boost protein secretion in microorganisms through the recombinant plasmid.
Career Highlights
Throughout his career, Kazuaki Manabe has worked with reputable organizations, including the Agency of Industrial Science and Technology and the Ministry of International Trade and Industry. His positions in these institutions have significantly influenced his research and inventions, further pushing the boundaries of biotechnology.
Collaborations
Kazuaki Manabe has collaborated with notable colleagues, including Yoshio Furutani and Noboru Tomioka. These partnerships have contributed to the richness of his research and the successful realization of his innovative inventions.
Conclusion
Kazuaki Manabe's dedication to biotechnology and his pioneering work in recombinant DNA technology have made him a distinguished inventor. His patents not only illustrate his inventive capabilities but also showcase the potential for revolutionary advancements in microbial protein production. Through his research and collaborations, Manabe continues to inspire the next generation of scientists and innovators in the field.