Katja M Arndt

Title: Katja M Arndt: Innovator in Protein-Protein Interaction Screening

Introduction

Katja M Arndt is a notable inventor based in Freiburg, Germany. She has made significant contributions to the field of protein-protein interactions, holding 2 patents that showcase her innovative approaches.

Latest Patents

Her latest patents describe a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. This invention allows for the screening of a protein library against a second protein library, facilitating numerous applications in the study of protein-protein interactions. The methodology involves the use of two leucine zipper libraries, which were genetically fused to fragments of the enzyme murine dihydrofolate reductase (mDHFR). The interaction between the library polypeptides is essential for reconstituting the enzymatic activity of mDHFR, which enables bacterial growth. By applying different selection stringencies, Arndt has enriched the best-performing leucine zipper pairs, amplifying small differences among the pairs through competitive growth.

Career Highlights

Katja M Arndt is currently associated with Odyssey Thera Inc., where she continues to advance her research in protein interactions. Her work has been pivotal in enhancing the understanding of protein dynamics and their applications in various biological contexts.

Collaborations

She has collaborated with notable colleagues, including Stephen William Watson Michnick and Joelle Nina Pelletier, contributing to a rich exchange of ideas and innovations in her field.

Conclusion

Katja M Arndt's work exemplifies the intersection of innovation and practical application in the realm of protein research. Her contributions are paving the way for future advancements in understanding protein interactions and their implications in biological systems.