Kathleen Triplett

Title: Innovations in Vaccine Development by Kathleen Triplett

Introduction

Kathleen Triplett is an accomplished inventor based in Albuquerque, NM (US). She has made significant contributions to the field of vaccine development, particularly in the area of virus-like particles (VLPs). Her innovative work focuses on creating immunogenic compositions that can effectively target virulence factors in pathogens.

Latest Patents

Kathleen Triplett holds a patent for "VLP-based vaccines for targeting secreted virulence factors." This invention is directed to engineered virus-like particles that present epitopes from Staphylococcus aureus (SA), specifically autoinducing peptides (AIPs) that regulate quorum-sensing dependent virulence. The VLPs can be utilized to develop efficacious vaccines and immunogenic compositions. In preclinical studies using a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs has shown to induce protective immunity, limiting the pathogenesis of SA infection and promoting bacterial clearance.

Career Highlights

Kathleen is associated with UNM Rainforest Innovations, where she continues to advance her research and development efforts. Her work has the potential to significantly impact public health by providing new strategies for combating bacterial infections.

Collaborations

She collaborates with notable colleagues, including Pamela Hall and Bryce Chackerian, who contribute to her research endeavors and help drive innovation in the field.

Conclusion

Kathleen Triplett's work in developing VLP-based vaccines represents a promising advancement in the fight against bacterial infections. Her innovative approach and dedication to research are paving the way for future breakthroughs in immunology.