The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Feb. 01, 2017
Stc.unm, Albuquerque, NM (US);
Pamela Hall, Albuquerque, NM (US);
Bryce Chackerian, Albuquerque, NM (US);
David S. Peabody, Albuquerque, NM (US);
Seth Michael Daly, Albuquerque, NM (US);
Bradley Owen Elmore, Worthington, MN (US);
Kathleen Triplett, Albuquerque, NM (US);
UNM Rainforest Innovations, Albuquerque, NM (US);
Abstract
The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from(SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.