Kateri Moore

Title: Kateri Moore: Innovator in Hematopoietic Stem Cell Research

Introduction

Kateri Moore is a prominent inventor based in Princeton, NJ (US). She has made significant contributions to the field of hematopoietic stem cell research, holding 2 patents that focus on innovative methods for cell programming and differentiation.

Latest Patents

One of her latest patents is titled "Methods for programming differentiated cells into hematopoietic stem cells." This patent discloses the development of methods for creating hematopoietic stem cells from differentiated cells by introducing and expressing specific transcription factors. The methods aim to redirect differentiated cells to either a hematopoietic stem cell state or a hemogenic endothelial cell state through direct programming with particular combinations of transcription factors.

Another notable patent is "Use of delta-like protein to inhibit the differentiation of stem cells." This research investigates the role of primitive hematopoietic stem cells in discrete in vivo microenvironments, known as "niches," which provide molecular signals for stem cell differentiation and self-renewal. Moore's work has dissected the fetal liver microenvironment into distinct cellular components, establishing a panel of stromal cell lines. One specific cell line has been shown to maintain repopulating stem cells for extended in vitro culture periods. The research also identifies a cDNA encoding a cell surface glycoprotein, dlk/Pref-1, which is related to the Notch/Delta/Serrate family of proteins. The study demonstrates that the dlk protein promotes the formation of "cobblestone areas" of proliferation, containing both primitive high-proliferative potential progenitors and in vivo repopulating stem cells.

Career Highlights

Kateri Moore has worked at notable institutions, including the Icahn School of Medicine at Mount Sinai. Her research has significantly advanced the understanding of stem cell biology and its applications in regenerative medicine.

Collaborations

Throughout her career, Moore has collaborated with esteemed colleagues such as Ihor R Lemischka and Larry Witte. Their joint efforts have contributed to the advancement of knowledge in hematopoietic stem cell research.

Conclusion

Kateri Moore's innovative work in hematopoietic stem cell research has led to valuable patents and collaborations that enhance our understanding of stem cell biology. Her contributions are paving the way for future advancements in regenerative