The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Jan. 30, 2013
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Ihor R. Lemischka, Princeton, NJ (US);
Kateri Moore, Princeton, NJ (US);
Carlos Filipe Pereira, New York, NY (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0789 (2010.01); G01N 33/483 (2006.01); G01N 33/50 (2006.01); A61K 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0647 (2013.01); G01N 33/5014 (2013.01); A61K 35/00 (2013.01); C12N 2501/60 (2013.01); C12N 2501/998 (2013.01); C12N 2502/1394 (2013.01); C12N 2506/13 (2013.01); C12N 2510/00 (2013.01);
Abstract
The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.