Company Filing History:
Years Active: 1998-2006
Title: Innovations of Kaspar-Philipp Holliger
Introduction
Kaspar-Philipp Holliger is a notable inventor based in Cambridge, GB. He has made significant contributions to the field of biotechnology, particularly in the development of binding proteins. His work has led to the filing of multiple patents, showcasing his innovative approach to scientific challenges.
Latest Patents
Holliger holds 2 patents that focus on multivalent and multispecific binding proteins. His latest patent describes polypeptides that comprise a first domain, which includes a binding region of an immunoglobulin heavy chain variable region, and a second domain, which includes a binding region of an immunoglobulin light chain variable region. These domains are linked but are incapable of associating with each other to form an antigen binding site. Instead, they associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains can be linked by a short peptide linker or may be joined directly together, with bispecific dimers potentially having longer linkers. The patent also discloses methods of preparation for the polypeptides and multimers, as well as their display on the surface of bacteriophage for easy selection of binders of interest, along with various utilities.
Career Highlights
Throughout his career, Holliger has worked with esteemed organizations such as the Medical Research Council and Cambridge Antibody Technology Limited. His experience in these institutions has allowed him to refine his skills and contribute to groundbreaking research in the field of immunology.
Collaborations
Holliger has collaborated with notable colleagues, including Andrew David Griffiths and Magnus Malmqvist. These partnerships have further enhanced his research and innovation capabilities.
Conclusion
Kaspar-Philipp Holliger's contributions to the field of biotechnology through his patents and collaborations highlight his role as a leading inventor. His work continues to influence advancements in binding protein technology.
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