The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2006
Filed:
Sep. 20, 2002
Kaspar-philipp Holliger, Cambridge, GB;
Andrew David Griffiths, Cambridge, GB;
Hendricus Renerus Jacobus Matheus Hoogenboom, Hasselt, BE;
Magnus Malmqvist, Uppsala, SE;
James David Marks, Kensington, CA (US);
Brian Timothy Mcguinness, Cambridge, GB;
Anthony Richard Pope, Cambridge, GB;
Terence Derek Prospero, Cambridge, GB;
Gregory Paul Winter, Cambridge, GB;
Kaspar-Philipp Holliger, Cambridge, GB;
Andrew David Griffiths, Cambridge, GB;
Hendricus Renerus Jacobus Matheus Hoogenboom, Hasselt, BE;
Magnus Malmqvist, Uppsala, SE;
James David Marks, Kensington, CA (US);
Brian Timothy McGuinness, Cambridge, GB;
Anthony Richard Pope, Cambridge, GB;
Terence Derek Prospero, Cambridge, GB;
Gregory Paul Winter, Cambridge, GB;
Medical Research Council, London, GB;
Abstract
Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.