Hendricus Renerus Jacobus Matheus Hoogenboom

Title: Innovations of Hendricus Renerus Jacobus Matheus Hoogenboom

Introduction

Hendricus Renerus Jacobus Matheus Hoogenboom is a notable inventor based in Hasselt, Belgium. He has made significant contributions to the field of biochemistry, particularly in the development of binding proteins. With a total of 2 patents to his name, his work has implications for various applications in medical research.

Latest Patents

Hoogenboom's latest patents focus on multivalent and multispecific binding proteins. These polypeptides consist of a first domain, which includes a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region. The domains are linked but do not associate with each other to form an antigen binding site. Instead, they associate to form antigen binding multimers, such as dimers, which may be multivalent or exhibit multispecificity. The domains can be linked by a short peptide linker or joined directly together, with bispecific dimers potentially having longer linkers. The patents also disclose methods for preparing these polypeptides and multimers, as well as their display on the surface of bacteriophage for easy selection of binders of interest.

Career Highlights

Hoogenboom is affiliated with the Medical Research Council, where he continues to advance his research in binding proteins. His work is crucial for the development of new therapeutic strategies and diagnostic tools.

Collaborations

He has collaborated with notable colleagues, including Andrew David Griffiths and Magnus Malmqvist, contributing to a rich environment of innovation and research.

Conclusion

Hendricus Renerus Jacobus Matheus Hoogenboom's contributions to the field of binding proteins highlight his role as a significant inventor in medical research. His patents pave the way for advancements in therapeutic applications and diagnostics.