Company Filing History:
Years Active: 1998-1999
Title: Jurgen Distler: Innovator in Acarbose Biosynthesis
Introduction
Jurgen Distler is a notable inventor based in Wuppertal, Germany. He has made significant contributions to the field of biochemistry, particularly in the area of acarviosyl transferase and acarbose biosynthesis. With a total of 2 patents, his work has implications for both scientific research and industrial applications.
Latest Patents
Distler's latest patents focus on processes for preparing acarviosyl transferase and utilizing it effectively. The first patent relates to the isolation, purification, and characterization of acarviosyl transferase derived from actinomycetes, specifically from Actinoplanes sp. SE 50/110 and its mutants. This invention outlines methods for converting acarbose minor constituents into acarbose or preparing acarbose homologues. Additionally, it discusses the use of acarviosyl transferase in acarbose purification and the development of production mutants to reduce the formation of minor constituents.
The second patent addresses acarbose biosynthesis genes from actinomycetes, predominantly from Actinoplanes sp. SE 50/110. This invention details a process for isolating acarbose biosynthesis genes using a gene probe derived from conserved protein regions of known dTDP-glucose dehydratase enzymes. It identifies key genes such as acbA, acbB, and acbC, which are essential for acarbose production.
Career Highlights
Jurgen Distler has had a distinguished career at Bayer Aktiengesellschaft, where he has been instrumental in advancing research in biochemistry and enzyme technology. His innovative approaches have led to significant advancements in the understanding and application of acarviosyl transferase and acarbose biosynthesis.
Collaborations
Throughout his career, Distler has collaborated with esteemed colleagues, including Anneliese Crueger and Wolfgang Piepersberg. These partnerships have fostered a collaborative environment that enhances research outcomes and drives innovation in the field.
Conclusion
Jurgen Distler's contributions to the field of biochemistry, particularly in acarviosyl transferase and acarbose biosynthesis, highlight his role as a leading inventor. His patents not only advance scientific knowledge but also have practical applications in industry.