The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1999
Filed:
Mar. 14, 1997
Anneliese Crueger, Erkrath, DE;
Hans-Georg Dellweg, Wuppertal, DE;
Jurgen Georg Lenz, Leverkusen, DE;
Werner Schroder, Wuppertal, DE;
Hermann Pape, Munster, DE;
Klaus Goeke, Menden, DE;
Beate Schaper, Munster, DE;
Michael Hemker, Munster, DE;
Wolfgang Piepersberg, Wuppertal, DE;
Jurgen Distler, Wuppertal, DE;
Ansgar Stratmann, Hattingen, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
The invention relates to acarviosyl transferase from actinomycetes, mainly from Actinoplanes sp. SE 50/110 and its mutants, to a process for isolating, purifying and characterizing the enzyme, to the isolation and characterization of the acbD gene encoding the acarviosyl transferase, to the expression of the acarviosyl transferase in a heterologous host organism, to the use of the acarviosyl transferase for converting acarbose minor constituents into acarbose or for preparing acarbose homologues, to the use of the acarviosyl transferase in acarbose purification, and also to the preparation of production mutants in which formation of minor constituents is reduced by means of inactivation of the acarviosyl transferase gene.