Company Filing History:
Years Active: 2020-2024
Title: Junling Guo: Innovator in Gene Engineering and Enzyme Engineering
Introduction
Junling Guo is a prominent inventor based in Wuxi, China. He has made significant contributions to the fields of gene engineering and enzyme engineering. With a total of 6 patents to his name, Guo's work has the potential to impact various scientific and industrial applications.
Latest Patents
One of Guo's latest patents is a method for constructing efficient promoters. This method involves connecting natural promoters identified by different sigma subunits in series to create double-series and triple-series promoters. The optimization of intervening sequences between core areas of the promoters enhances their activity. This innovative approach allows for better compatibility with other gene expression regulating elements and enables controllable regulation of exogenous gene expression. The method is simple to implement and holds promise for applications in synthetic biology and the construction of efficient expression systems for exogenous proteins.
Another notable patent is the mutant of nitrile hydratase derived from his research. The mutant, known as Nhase-A20V, exhibits a half-life of about 10 minutes at 70° C., maintaining thermal stability similar to the wild enzyme. This mutant demonstrates a specific enzyme activity that is 128% of that of the wild enzyme, along with improved tolerance to substrates and products. The final yield of nicotinamide produced through whole-cell catalysis reaches an impressive 598 g/L, showcasing the mutant's beneficial enzymatic properties for future industrial production.
Career Highlights
Junling Guo is affiliated with Jiangnan University, where he continues to advance his research in enzyme engineering and gene engineering. His innovative work has garnered attention in the scientific community, contributing to the development of new methodologies and applications in these fields.
Collaborations
Guo has collaborated with notable colleagues, including Zhemin Zhou and Zhongmei Liu, further enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Junling Guo's contributions to gene engineering and enzyme engineering exemplify the innovative spirit of modern science. His patents reflect a commitment to advancing technology and improving industrial processes. Through his work, Guo continues to pave the way for future advancements in these critical fields.