Location History:
- Clarksburg, VA (US) (2013)
- Bethesda, MD (US) (2015)
Company Filing History:
2 out of 1,506 
2 out of 3,539 
1 out of 208 
Years Active: 2013-2015
Title: Innovations in Hepatocellular Carcinoma Research by Junfang Ji
Introduction
Junfang Ji is a prominent inventor based in Bethesda, MD (US), known for his significant contributions to the field of hepatocellular carcinoma (HCC) research. He holds 2 patents that focus on innovative methods for predicting clinical outcomes and identifying therapeutic agents for HCC patients.
Latest Patents
His latest patents include groundbreaking work on the use of the MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy. This invention reveals that the expression of microRNA-26 is decreased in HCC tumor tissue compared to non-cancerous tissue. A low level of microRNA-26 is associated with poor clinical outcomes, and it is correlated with a favorable response to interferon (IFN)-α therapy in HCC patients. The patent provides methods for predicting clinical outcomes and selecting patients for IFN-α therapy based on microRNA-26 expression levels. Additionally, it outlines methods for identifying therapeutic agents that can increase microRNA-26 expression in HCC cells.
Another significant patent focuses on determining HCC subtypes and detecting hepatic cancer stem cells. This invention includes methods for obtaining samples, assaying biomarkers, and correlating their expression with HCC subtypes. It also provides methods for detecting HCC stem cells and offers compositions for treating subjects with HCC based on these biomarkers.
Career Highlights
Junfang Ji has worked at esteemed institutions such as The Ohio State University and the National Institutes of Health, a component of the US Department of Health & Human Services. His work has significantly advanced the understanding of HCC and its treatment.
Collaborations
He has collaborated with notable colleagues, including Xin Wei Wang and Carlo M Croce, contributing to the collective knowledge and research in the field of cancer treatment.
Conclusion
Junfang Ji's innovative research and patents have made a substantial impact on the understanding and treatment of hepatocellular carcinoma. His work continues to pave the way for advancements in cancer therapy and patient care.