Judith Ann Potashkin

Title: Judith Ann Potashkin: Innovator in Parkinson's Disease Research

Introduction

Judith Ann Potashkin is a prominent inventor based in North Chicago, IL (US). She has made significant contributions to the field of medical research, particularly in the diagnosis and treatment of Parkinson's disease. With a total of 3 patents, her work has the potential to impact the lives of many patients suffering from this debilitating condition.

Latest Patents

Potashkin's latest patents include groundbreaking methods and kits for diagnosing, prognosing, and monitoring Parkinson's disease. One of her notable inventions involves a network-based meta-analysis of four independent microarray studies. This research identified the hepatocyte nuclear factor (HNF4A) as a central regulatory hub gene that is upregulated in the blood of Parkinson's disease patients. In contrast, the polypyrimidine tract binding protein 1 (PTBP1) was found to be the most downregulated gene. Using these markers, Potashkin's methods classified Parkinson's disease patients with 90% sensitivity and 80% specificity. Longitudinal performance analysis demonstrated that the relative abundance of HNF4A and PTBP1 mRNAs significantly changed in Parkinson's disease patients over a three-year follow-up period. This inverse regulation provides a molecular rationale for the altered insulin signaling observed in these patients.

Another significant patent focuses on the screening, diagnosing, treating, and prognosis of pathophysiologic status by RNA regulation. This invention describes the relationship between cancer and ribonucleic acid (RNA) regulation by determining intracellular levels of RNA regulators. It highlights that mRNA levels are often decreased in cancer cells, which may reflect reduced mRNA expression or increased degradation. Potashkin's work demonstrates an effective clinical management strategy for uterine cell cancers by leveraging the relationship between P2X mRNA and specific miRNAs.

Career Highlights

Throughout her career, Judith Ann Potashkin has worked with esteemed institutions such as Rosalind Franklin University of Medicine and Science and University Hospitals Cleveland Medical Center. Her research has garnered attention for its innovative approach to understanding complex diseases.

Collaborations

Potashkin has collaborated with notable colleagues, including George Gorodeski and Bentley Cheatham, to advance her research and develop impactful solutions in the medical field.

Conclusion

Judith Ann Potashkin's contributions to the