The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Mar. 13, 2008
George Gorodeski, Beachwood, OH (US);
Judith Potashkin, Gurnee, IL (US);
Bentley Cheatham, Durham, NC (US);
George Gorodeski, Beachwood, OH (US);
Judith Potashkin, Gurnee, IL (US);
Bentley Cheatham, Durham, NC (US);
University Hospitals Cleveland Medical Center, Cleveland, OH (US);
Rosalind Franklin University of Medicine and Science, an Illinois Corporation, North Chicago, IL (US);
Abstract
A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that may be a reflection of either reduced mRNA expression and/or increased mRNA degradation. miRNAs are identified that hybridize to an mRNA that are suspected to mediate intracellular mRNA steady state levels. Alternatively, ribonucleic acid binding protein (RBP) levels may also mediate intracellular mRNA steady state levels. In particular, this invention demonstrates an effective clinical management strategy for uterine cell cancers may be implemented by taking advantage of an exemplary relationship between P2XmRNA and miRNAs including, but not limited to, miR-186 and/or miR-150.