Company Filing History:
5 out of 1,935 
2 out of 291 
1 out of 243 
Years Active: 2019-2024
Title: Innovations by Inventor Juan R. Del Valle
Introduction
Juan R. Del Valle is a prominent inventor based in Tampa, Florida, known for his groundbreaking contributions to cancer research. With a total of seven patents to his name, he has established himself as a leader in developing innovative therapies targeting B cell cancers and other malignancies.
Latest Patents
Among his latest patents is a significant invention titled "Inhibitors of the IRE-1/XBP-1 pathway and methods of using thereof." This patent discloses XBP-1/IRE-1 inhibitors and elaborates on methods for their use in cancer treatment, specifically targeting B cell cancers. The invention also includes a genetic XBP-1-knockout cancer mouse model, providing a critical tool for understanding cancer biology.
Another notable patent is for "Substituted chromenones, IRE1 inhibitors, and methods of using same." This invention details substituted chromenones that inhibit the IRE1/XBP-1 pathway and describes their potential in treating cancers related to ER stress response activation. The research highlights how secretory IgM can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) in various tumor models, including solid tumors like lung cancer. The implications of inhibiting the IRE1/XBP-1 pathway to reduce MDSC levels in tumors are particularly promising.
Career Highlights
Juan R. Del Valle has made significant strides in his career through his affiliations with prestigious institutions. He has worked at the University of South Florida and the H. Lee Moffitt Cancer Center and Research Institute, Inc. His endeavors have greatly contributed to advancing cancer treatment methodologies.
Collaborations
Throughout his career, Del Valle has collaborated with notable colleagues such as Lindsey Neil Shaw and Chih-Chi Andrew Hu. These partnerships have fostered a collaborative environment that has propelled innovative research in the realm of cancer therapies.
Conclusion
Juan R. Del Valle exemplifies the spirit of innovation and invention within the medical field, especially in cancer research. With a portfolio of patents that reflects his commitment to improving cancer treatment options, his work continues to inspire future advancements in the fight against cancer.