Location History:
- Redwood City, CA (US) (2019)
- San Carlos, CA (US) (2009 - 2022)
- Wellesley, MA (US) (2022)
Company Filing History:
21 out of 152 
13 out of 1,624 
9 out of 3,681 
Years Active: 2009-2022
Title: Josephine M. Cardarelli: A Pioneer in Monoclonal Antibody Research
Introduction
Josephine M. Cardarelli, based in San Carlos, California, is a notable inventor with an impressive portfolio of 43 patents. Her groundbreaking work primarily revolves around human monoclonal antibodies, which have significant implications in treating various cancers and inflammatory disorders.
Latest Patents
Among her latest patents, Cardarelli has been recognized for her remarkable innovation in the field of immunology with her patent on human monoclonal antibodies that bind CXCR4 and their uses. This patent outlines isolated monoclonal antibodies that exhibit high affinity toward the CXCR4 receptor. Additionally, the disclosure includes nucleic acid molecules encoding these antibodies, expression vectors, and host cells, along with methods for effective antibody expression. The patents also introduce immunoconjugates, bispecific molecules, and pharmaceutical compositions including her antibodies. Furthermore, methods for detecting CXCR4 and treating conditions such as various cancers, inflammatory disorders, and HIV infections using anti-CXCR4 antibodies are emphasized in her work.
Another significant patent addresses the treatment of Waldenstrom's macroglobulinemia, providing a method for treating patients afflicted with this condition by administering an antibody that specifically binds to the CXCR4 receptor on WM cells. This innovative approach showcases her dedication to advancing therapeutic strategies in oncology.
Career Highlights
Cardarelli has made significant contributions during her tenure at renowned companies like Medarex Inc. and E.R. Squibb & Sons, LLC. Her work in these organizations has not only enriched her professional journey but has also led to the development of critical therapeutic interventions.
Collaborations
Throughout her career, Cardarelli has collaborated with esteemed colleagues, including Mohan Srinivasan and Alison Witte. These partnerships have enabled the exchange of ideas and fostered innovation, further enhancing the landscape of monoclonal antibody research.
Conclusion
Josephine M. Cardarelli's contributions to the field of monoclonal antibodies underscore her status as a distinguished inventor. With her 43 patents, she is paving the way for novel therapeutic solutions that hold the potential to change lives and improve treatment outcomes for patients facing challenging health conditions. Her commitment to innovation and collaboration continues to inspire the scientific community.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.