Company Filing History:
Years Active: 1987-1996
Title: Josephine Grosch: Innovator in Protease Technology
Introduction
Josephine Grosch is a notable inventor based in Elkhart, Indiana, recognized for her contributions to the field of protease technology. With two patents to her name, she has made significant advancements that have practical applications in various industries, particularly in the development of detergent additives.
Latest Patents
One of Grosch's latest patents is titled "Proteases of altered stability to autolytic degradation." This invention addresses the susceptibility of proteases to autolytic degradation. The method outlined in the patent provides a way to identify susceptible autolysis sites that can be cleaved to produce discrete fragments. By chemically modifying the amino acids at or near the cleavage site or altering the DNA sequence encoding these amino acids through site-directed mutagenesis, Grosch's invention aims to produce autolysis-stable proteases. This innovation is particularly beneficial for alkaline proteases, which are produced in large quantities and used as detergent additives. The stable alkaline proteases developed through this method could enhance the effectiveness of liquid detergent formulations.
Another significant patent by Grosch is the "Method for detection and isolation of a microorganism." This method allows for the detection of microorganisms that produce desired substances. It involves overlaying a membrane on an agar surface in a specific orientation, allowing microorganisms to grow on the membrane while the substance passes into the agar. After removing the membrane, a detectable reaction between the substance and one or more reagents can be observed. This method not only helps in locating the microorganism but also facilitates its isolation.
Career Highlights
Throughout her career, Grosch has worked with prominent companies such as Solvay Enzymes, Inc. and Miles Laboratories, Inc. Her work in these organizations has contributed to her expertise in enzyme technology and microbiology.
Collaborations
Grosch has collaborated with notable colleagues, including George Boguslawski and John W. Shultz. These collaborations have likely enriched her research and development efforts, leading to innovative solutions in her field.
Conclusion
Josephine Grosch's contributions to protease technology and her innovative patents demonstrate her significant impact on the industry. Her work continues to influence the development of effective solutions in various applications, particularly in the realm of detergents.