Company Filing History:

8 out of 8

North American Vaccine, Inc.

patents

6 out of 712

The Rockefeller University

patents

5 out of 2,480

Baxter International Inc.

where one patent can have more than one assignee

Years Active: 1984-2008

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14 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 7332173 - Group A streptococcal polysaccharide immunogenic compositions and methods (2008-02-19),

2. 6764686 - Modified immunogenic pneumolysin compositions as vaccines (2004-07-20),

3. 6602508 - Method of immunization using a Group B Streptococcus type II and type III polysaccharide conjugate vaccine (2003-08-05),

4. 6372222 - Antigenic group B Streptococcus type II and type III polysaccharide fragments having a 2, 5-anhydro-D-mannose terminal structure and conjugate vaccine thereof (2002-04-16),

5. 6284884 - Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof (2001-09-04),

6. 6280738 - Non-IgA Fc binding forms of the group B streptococcal &bgr; antigens (2001-08-28),

7. 6153406 - Method for the high level expression, purification and refolding of the (2000-11-28),

8. 6013267 - Method for the high level expression, purification and refolding of the (2000-01-11),

9. 5879686 - Method for the high level expression, purification and refolding of the (1999-03-09),

10. 5866135 - Group A streptococcal polysaccharide immunogenic compositions and methods (1999-02-02),

11. 5747287 - Method for the high level expression, purification and refolding of the (1998-05-05),

12. 5439808 - Method for the high level expression, purification and refolding of the (1995-08-08),

13. 5425946 - Vaccines against group C Neisseria meningitidis (1995-06-20),

14. 4459286 - Coupled H. influenzae type B vaccine (1984-07-10),

Title: Innovations and Contributions of Joseph Y Tai

Introduction

Joseph Y Tai is a prominent inventor based in Fort Washington, PA (US), known for his significant contributions to the field of immunology. With a total of 14 patents to his name, Tai has developed innovative solutions aimed at combating infectious diseases, particularly those caused by group A Streptococci and pneumolysin.

Latest Patents

One of Tai's latest patents is focused on group A streptococcal polysaccharide immunogenic compositions and methods. This invention provides a novel immunogenic composition and vaccine, along with processes for producing them and methods for immunization against infections and diseases caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization involves administering an immunogenic amount of group A polysaccharide, which may be given as a vaccine either on its own, conjugated to proteins, or conjugated to liposomes. This invention is particularly beneficial for providing both active and passive immunogenic protection for high-risk populations, including adults, pregnant women, infants, and children.

Another significant patent by Tai relates to modified immunogenic pneumolysin compositions as vaccines. This invention involves modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but exhibit reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also outlines a method for generating novel pneumolysin variants with these desired properties. The immunogenic compositions can be used as pharmaceutical formulations, including vaccines, where non-toxic, modified pneumolysin stimulates protective immunity. Additionally, the invention provides a method for using the non-toxic, modified pneumolysin toxoid to stimulate antibodies in a treated individual, which can then be isolated and transferred to another individual, thereby conferring protection.

Career Highlights

Throughout his career, Joseph Y Tai has worked with notable organizations, including North American Vaccine, Inc. and The Rockefeller University. His work has significantly advanced the understanding and treatment of infectious diseases, showcasing his dedication to public health and innovation.

Collaborations

Tai has collaborated with esteemed colleagues, including Milan S Blake and Shu-Mei Liang, contributing to the development of groundbreaking immunological research and applications.

Conclusion

Joseph Y Tai's innovative work in

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