The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 1995
Filed:
Jul. 23, 1993
Milan S Blake, New York, NY (US);
Joseph Y Tai, Fort Washington, PA (US);
Huilin L Qi, New York, NY (US);
Shu-Mei Liang, Bethesda, MD (US);
Lucjan J Hronowski, Laurel, MD (US);
Jeffrey K Pullen, Columbia, MD (US);
North American Vaccine, Inc., Beltsville, MD (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins yard fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.