Joseph O Rich

Title: Joseph O Rich: Innovator in Enzymatic Acylation

Introduction

Joseph O Rich is a notable inventor based in Iowa City, IA (US). He has made significant contributions to the field of enzymatic acylation, showcasing his expertise through his innovative patent.

Latest Patents

Joseph O Rich holds a patent for a method titled "Two step enzymatic acylation." This method provides a way to derivatize a compound that has a hydroxyl group through back-to-back acylation. The process involves acylating the compound with a bifunctional acyl donor in the presence of a hydrolase, resulting in the formation of an activated acyl ester or carbonate. The bifunctional acylating donor is preferably a di(vinyl) ester or carbonate. Subsequently, the activated acyl ester or carbonate is utilized to acylate a nucleophile in the presence of a lipase. This innovative method allows for regioselective enzymatic acylation of the base compound.

Career Highlights

Joseph O Rich is associated with Albany Molecular Research, Inc., where he applies his knowledge and skills in the field of enzymatic processes. His work has contributed to advancements in chemical methodologies and applications.

Collaborations

Some of his notable coworkers include Yuri L Khmelnitsky and Cheryl L Budde, who have collaborated with him on various projects within the company.

Conclusion

Joseph O Rich's contributions to enzymatic acylation through his innovative patent highlight his role as a significant inventor in the field. His work continues to influence advancements in chemical methodologies.