The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2001
Filed:
Nov. 23, 1998
Yuri L. Khmelnitsky, Coralville, IA (US);
Cheryl L. Budde, Coralville, IA (US);
John M. Arnold, Coralville, IA (US);
Joseph O. Rich, Iowa City, IA (US);
Sharon S. Chen, Pasadena, CA (US);
Alexander Ya. Usyatinsky, Coralville, IA (US);
Douglas S. Clark, Orinda, CA (US);
Jonathan S. Dordick, Schenectady, NY (US);
Albany Molecular Research, Inc., Albany, NY (US);
Abstract
A method for derivatizing a compound having a hydroxyl group by back to back acylation is provided. The compound is acylated with a bifunctional acyl donor in the presence of a hydrolase to form an activated acyl ester or carbonate. Preferably the bifunctional acylating donor is a di(vinyl) ester or carbonate. The activated acyl ester or carbonate is then used to acylate a nucleophile in the presence of a lipase. The method of the invention provides regioselective enzymatic acylation of the base compound.