Company Filing History:
Years Active: 2021-2023
Title: Joseph McGraw: Innovator in CYP450 Enzyme Phenotyping
Introduction
Joseph McGraw is a notable inventor based in Germantown, WI (US). He has made significant contributions to the field of pharmacogenomics, particularly in the phenotyping of cytochrome P450 enzymes. With a total of 2 patents, his work has the potential to enhance personalized medicine.
Latest Patents
McGraw's latest patents include innovative methods for phenotyping the CYP3A5 enzyme activity in saliva samples. The first patent discloses methods and compositions that utilize eplerenone as a substrate for CYP3A5. This substrate can be administered orally, allowing for the detection of eplerenone metabolites in saliva. This process helps calculate a metabolic ratio for the CYP3A5 enzyme, generating a phenotypic profile for the subject. The second patent focuses on a mélange of substrates for various CYP450 enzymes, also administered orally. This method enables the detection of metabolites in saliva, facilitating the calculation of metabolic ratios for different CYP450 enzymes to create a comprehensive phenotypic profile.
Career Highlights
Throughout his career, McGraw has worked with esteemed institutions such as Concordia University and Cu Ventures, Inc. His research has contributed to advancements in understanding enzyme activity and its implications for drug metabolism.
Collaborations
Some of his notable coworkers include Armin Henry Gerhardt and Armin Gerhardt. Their collaborative efforts have furthered the research in the field of enzyme phenotyping.
Conclusion
Joseph McGraw's innovative work in CYP450 enzyme phenotyping represents a significant advancement in personalized medicine. His patents and collaborations highlight his commitment to improving healthcare through scientific research.