Company Filing History:
4 out of 7 
4 out of 258 
3 out of 3 
Years Active: 1976-2000
Title: The Innovations of Joseph J. Zimmermann: Enzymatic Advances in Chondroitin Degradation
Introduction
Joseph J. Zimmermann, an inventive force hailing from Elm Grove, Wisconsin, has made significant contributions to the realm of biochemistry through his work on chondroitin lyase enzymes. With a remarkable portfolio of 13 patents, Zimmermann showcases his dedication to pioneering advancements that have far-reaching implications in the scientific and medical communities.
Latest Patents
Among his notable patents, Zimmermann's innovations regarding chondroitin lyase enzymes stand out. This invention describes a comprehensive method for producing two highly purified enzymes capable of degrading chondroitin sulfate polysaccharides. The intricate purification process involves various techniques, including cell disruption, cation exchange chromatography, affinity chromatography, hydroxylapatite chromatography, high-resolution ion exchange chromatography, and size exclusion. The result is the isolation of two proteins: a 77,000 ± 5,000 Dalton protein capable of degrading chondroitin sulfates A and C, and a 55,000 ± 2,300 Dalton protein effective against dermatan sulfate. Furthermore, the genes encoding these enzymes, known as chondroitinase AC and chondroitinase B, have been successfully cloned, and methods for their practical applications are thoroughly described in his patents.
Career Highlights
Zimmermann’s career spans several pivotal roles in prominent companies. He has been associated with reputable firms such as Ibex Technologies Ltd. and GTE Automatic Electric Laboratories Incorporated. These experiences have undoubtedly enriched his expertise and fuelled his passion for innovation in enzymatic research.
Collaborations
Joseph J. Zimmermann has collaborated with esteemed colleagues such as Kangfu Gu and Clark Bennett. These partnerships further exemplify the collaborative spirit required to advance scientific knowledge and technological applications in the field.
Conclusion
Joseph J. Zimmermann’s inventive journey is a testament to his remarkable contributions to enzymatic research, particularly in the development of chondroitin lyase enzymes. His extensive patent portfolio and impactful collaborations highlight the vital role he plays in the ongoing evolution of biotechnology, propelling advancements that benefit both the scientific community and society at large.