Joseph E Rabinowitz

Title: Joseph E Rabinowitz: Innovator in Gene Therapy

Introduction

Joseph E Rabinowitz is a notable inventor based in Elkins Park, PA (US). He has made significant contributions to the field of gene therapy, particularly in the development of viral vectors for delivering therapeutic molecules. With a total of 2 patents, his work has the potential to impact various medical conditions.

Latest Patents

Rabinowitz's latest patents include innovative constructs and methods for delivering molecules via viral vectors with blunted innate immune responses. One of his patents describes a CpG-modified recombinant adeno-associated viral (AAV) vector. This vector carries a nucleic acid molecule that comprises AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence. The regulatory sequences control the expression of the gene product, and the nucleic acid sequences are modified to significantly reduce CpG di-nucleotides. This modification helps to reduce the immune response to the vector compared to the unmodified AAV vector. Additionally, he has developed methods and regimens for delivering transgenes using these AAV viral vectors, significantly modulating the innate immune response to the vector and/or transgene.

Another significant patent focuses on tissue-specific gene therapy treatment. This invention provides nucleic acid segments, compositions, and methods for treating heart failure, vascular dysfunction, endothelial dysfunction, diabetes, calcium regulation, and nitric oxide synthase dysfunction. In this patent, adeno-associated and adenovirus are utilized as gene delivery vectors for the nucleic acid segments, promoting long-term over-expression of S100A1, a small calcium-sensing protein associated with the mentioned ailments and dysfunctions.

Career Highlights

Throughout his career, Joseph E Rabinowitz has worked with various institutions, including Thomas Jefferson University. His research has contributed to advancements in gene therapy and molecular delivery systems.

Collaborations

Rabinowitz has collaborated with notable colleagues such as Susan M Faust and James M Wilson. Their combined expertise has furthered the development of innovative therapeutic approaches.

Conclusion

Joseph E Rabinowitz is a pioneering inventor whose work in gene therapy and viral vector technology holds promise for treating various medical conditions. His contributions continue to influence the field and inspire future innovations.