The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2013
Filed:
Oct. 30, 2007
Walter J. Koch, Broomall, PA (US);
Patrick Most, Philadelphia, PA (US);
Sven T. Pleger, Heidelberg, DE;
Joseph E. Rabinowitz, Elkins Park, PA (US);
Walter J. Koch, Broomall, PA (US);
Patrick Most, Philadelphia, PA (US);
Sven T. Pleger, Heidelberg, DE;
Joseph E. Rabinowitz, Elkins Park, PA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Abstract
The invention provides nucleic acid segments, compositions and methods for the treatment of heart failure, vascular dysfunction, endothelial dysfunction, diabetes, [Ca]i regulation and NO synthase dysfunction. Adeno-associated and adenovirus are used as gene delivery vectors for the nucleic acid segments to product long term over-expression of S100A1, a small calcium sensing protein associated with the disclosed ailments and dysfunctions.