Joseph De Angelo

Title: Joseph De Angelo: Innovator in Hemoglobin Research

Introduction

Joseph De Angelo is a notable inventor based in Hamtramck, MI (US), recognized for his contributions to the field of hemoglobin research. He holds a total of 7 patents, showcasing his innovative approach to addressing critical physiological challenges.

Latest Patents

One of his latest patents is titled "Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein." This invention focuses on a method for preventing or treating systemic hypotension caused by nitric oxide production, which can be induced by biological response modifiers such as cytokines and endotoxins. Additionally, it addresses the treatment of septic shock. Another significant patent is "Expression of recombinant hemoglobin and hemoglobin variants in yeast." This invention involves the production of a substantially pure mammalian globin chain or heme-binding fragment, along with methods for expressing globin chains in yeast. The hemoglobin produced through these methods has potential applications as a physiological oxygen carrier, particularly in blood substitute solutions and plasma expanders.

Career Highlights

Throughout his career, Joseph De Angelo has worked with reputable organizations, including Apex Bioscience, Inc. and the University of Texas System. His work has significantly advanced the understanding and application of hemoglobin in medical science.

Collaborations

Joseph has collaborated with esteemed colleagues such as Joseph Bonaventura and Robert G Kilbourn, contributing to a rich exchange of ideas and innovations in his field.

Conclusion

Joseph De Angelo's innovative work in hemoglobin research and his numerous patents highlight his significant impact on medical science. His contributions continue to pave the way for advancements in treatments for critical health conditions.