Location History:
- Blawnox, PA (US) (2015 - 2023)
- Pittsburgh, PA (US) (2011 - 2024)
Company Filing History:
17 out of 1,860 
2 out of 3,370 
1 out of 2,595 
Years Active: 2011-2025
Title: Innovations by Joseph C. Glorioso, III: Pioneering Advances in Biomedical Research
Introduction
Joseph C. Glorioso, III, an accomplished inventor based in Pittsburgh, PA, has made significant contributions to the field of biomedical research through his innovative work. With a remarkable record of 18 patents, his inventions are paving the way for advanced therapeutic approaches, particularly in cancer treatment and pain management.
Latest Patents
Among his latest innovations, one of the most noteworthy is the **Oncolytic HSV vector**. This invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) that includes a non-HSV ligand specific for molecules present on the surface of target cells, such as cancer cells. The invention also incorporates microRNA target sequences into HSV gene loci, enhancing its efficacy in selectively killing tumor cells while sparing normal cells. Additionally, Glorioso has developed targeted methods for the **delivery of glycine receptors to excitable cells**. This method seeks to modulate the electrophysiological activity of excitable cells through exogenous expression of a GlyR protein, which can potentially control pain in subjects through novel pharmaceutical compositions.
Career Highlights
Glorioso's career has been marked by a notable tenure at the University of Pittsburgh, where he has dedicated his research efforts to the development of innovative therapies and has continued to push the boundaries of medical science. His work focuses on leveraging viral vectors and receptor modulation to address significant health challenges.
Collaborations
Throughout his career, Joseph C. Glorioso, III has collaborated with esteemed colleagues such as Justus B. Cohen and Hiroaki Uchida. These partnerships have been instrumental in driving forward his research and yielding impactful inventions that contribute to the advancement of biomedical science.
Conclusion
Joseph C. Glorioso, III's innovative spirit and dedication to advancing medical research have resulted in numerous patents, with the potential to make lasting impacts in the fields of oncology and pain management. His work exemplifies how targeted therapies can lead to improved treatment strategies, showcasing the importance of inventors in the evolution of healthcare solutions.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.