Company Filing History:
1 out of 111 
1 out of 33 Years Active: 1996-1997
Title: Innovations of Jonathan J Mitschelen
Introduction
Jonathan J Mitschelen is an accomplished inventor based in Perkiomenville, PA (US). He has made significant contributions to the field of biotechnology, particularly in the production and purification of viral particles and proteins. With a total of 2 patents, his work has advanced the understanding and application of viral technologies.
Latest Patents
Mitschelen's latest patents include a method for the production and purification of retroviral particles using tentacle anion exchange. This invention focuses on a continuous process for producing viral particles by maintaining a population of viable, virally infected non-lytic cells in a perfused growth medium. The process also involves purifying retroviral particles by passing a solution through an anion exchange resin, specifically a tentacle anion exchange resin, to effectively separate the viral particles from contaminants.
Another notable patent involves methods for the purification of recombinantly produced proteins. This process entails recovering the 52/48 kDa tryptic fragment of von Willebrand factor (vWF) from inclusion bodies produced in recombinant host cells. The method includes mechanical disruption of the cells, followed by a series of washings and centrifugation to isolate the desired protein fragments. Additionally, endotoxins and DNA are removed through a specific mechanical disruption process, ensuring the purity of the final product.
Career Highlights
Throughout his career, Mitschelen has worked with prominent companies in the pharmaceutical and biotechnology sectors. Notable among these are Rhone-Poulenc Rorer Pharmaceuticals Inc. and The Immune Response Corporation. His experience in these organizations has contributed to his expertise in viral technologies and protein purification.
Collaborations
Mitschelen has collaborated with several professionals in his field, including Michael E Hrinda and Thomas L Darling. These collaborations have likely enriched his research and development efforts, leading to innovative solutions in biotechnology.
Conclusion
Jonathan J Mitschelen's contributions to the field of biotechnology through his patents and career experiences highlight his role as a significant inventor. His work in the production and purification of viral particles and proteins continues to influence advancements in the industry.