The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 1997
Filed:
Mar. 11, 1996
Michael E Hrinda, Gwynedd Valley, PA (US);
Christopher P Prior, Wayne, PA (US);
Jonathan J Mitschelen, Perkiomenville, PA (US);
Thomas W Irish, Pottstown, PA (US);
David M Weber, Phoenixville, PA (US);
Richard S Gore, Southampton, PA (US);
James J Harter, Media, PA (US);
Pierre M Bay, Philadelphia, PA (US);
George C Tarr, Norristown, PA (US);
The Immune Response Corporation, Carlsbad, CA (US);
Abstract
This invention is directed to a continuous process for producing viral particles by providing in a perfused growth medium a population of viable virally infected non-lytic cells, and removing medium containing said cells at a rate to maintain the steady-state log-phase growth of cells remaining in the perfused growth medium. The invention is also directed to a process for purifying retroviral particles by passing a solution comprising the retroviral particles and contaminants through an anion exchange resin, and eluting the retroviral particles from the resin. The preferred exchange resin is a tentacle anion exchange resin.