Jonathan D Basch

Title: Innovations and Contributions of Jonathan D Basch

Introduction

Jonathan D Basch is a notable inventor based in East Syracuse, NY (US). He has made significant contributions to the field of biotechnology, particularly in the development of plasmids and mammalian cell culture processes. With a total of 5 patents to his name, Basch's work has had a considerable impact on protein production methodologies.

Latest Patents

Among his latest patents is the invention of a genetically stable plasmid that expresses PDH and FDH enzymes. This bi-cistronic plasmid is designed for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod). Another significant patent focuses on mammalian cell culture processes for protein production. This invention describes methods for producing proteins, particularly glycoproteins, through animal or mammalian cell culture. The process involves temperature shifts during the culturing period, which helps sustain high cell viability and increases the yield and quality of the protein product.

Career Highlights

Jonathan D Basch is currently associated with Bristol-Myers Squibb Company, where he continues to innovate and contribute to advancements in biotechnology. His work is characterized by a commitment to improving protein production techniques, which are crucial for various applications in medicine and research.

Collaborations

Throughout his career, Basch has collaborated with esteemed colleagues, including Shu-Jen Chiang and Bernhard M Schilling. These collaborations have further enhanced the quality and impact of his inventions.

Conclusion

Jonathan D Basch's contributions to biotechnology through his patents and innovative processes have established him as a key figure in the field. His work continues to influence the production of essential proteins, showcasing the importance of innovation in scientific research.