The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2005
Filed:
Dec. 17, 2002
Jonathan David Basch, DeWitt, NY (US);
Shu-jen David Chiang, Manlius, NY (US);
Suo-win Liu, Manlius, NY (US);
Akbar Nayeem, Newtown, PA (US);
Yuhua Sun, East Syracuse, NY (US);
LI You, Jamesville, NY (US);
Jonathan David Basch, DeWitt, NY (US);
Shu-Jen David Chiang, Manlius, NY (US);
Suo-Win Liu, Manlius, NY (US);
Akbar Nayeem, Newtown, PA (US);
Yuhua Sun, East Syracuse, NY (US);
Li You, Jamesville, NY (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.