Location History:
- Seattle, WA (US) (2011)
- Irvine, CA (US) (2022)
Company Filing History:
Years Active: 2011-2022
Title: Jonathan Anthony Claypool: Innovator in Nucleic Acid Capture and Controlled Lysis
Introduction
Jonathan Anthony Claypool is a distinguished inventor based in Seattle, WA. He has made significant contributions to the fields of biotechnology and molecular biology, holding a total of two patents that enhance the efficiency of nucleic acid purification and the controlled lysis of bacteria.
Latest Patents
Claypool's latest patents include inventive methods for nucleic acid capture and controlled lysis of bacteria. His first patent focuses on "Methods for nucleic acid capture," which details solutions, reagents, and methods for purifying nucleic acids. This innovation incorporates cationic surfactant solutions that, along with an optional anionic surfactant, facilitate phase separation and allow for the capture of nucleic acids, such as plasmid or genomic DNA, to a solid phase carrier like a mineral matrix.
The second patent, "Controlled lysis of bacteria," presents novel techniques for the gentle and efficient extraction of biological material from bacterial cells. It introduces engineered strains capable of rapid controlled autolysis triggered by the presence of saturating arabinose. This method showcases increased yields and purity of extracted proteins compared to traditional lysis methods, marking a significant advancement for research laboratories seeking optimal results in protein expression and nucleic acid extraction.
Career Highlights
Jonathan currently works at Zymo Research Corporation, a company recognized for its innovations in nucleic acid handling and purification. His work not only emphasizes practical applications but also aims to improve laboratory workflows.
Collaborations
Throughout his career, Claypool has teamed up with key coworkers, including Xiyu Jia and Jan Kostal. These collaborations have helped propel his research efforts and have contributed to the success of his inventions.
Conclusion
Jonathan Anthony Claypool's innovative mindset and dedication to advancing molecular biology techniques have led to the development of impactful patents. His work at Zymo Research Corporation continues to push the boundaries of biotechnology, ensuring more efficient methods for nucleic acid purification and bacterial lysis are available for researchers across various fields.