Company Filing History:
Years Active: 2019
Title: John W Craft: Innovator in Rho Associated Kinase Inhibitors
Introduction
John W Craft is a notable inventor based in Houston, TX (US). He has made significant contributions to the field of medical research, particularly in the development of peptide inhibitors for Rho-associated kinase (ROCK). His work focuses on addressing critical health issues, including heart failure, which is a leading cause of morbidity and mortality in the United States.
Latest Patents
John W Craft holds a patent for Rho associated kinase (ROCK) inhibitors and their use in treating various diseases. The patent describes peptide inhibitors that block ROCK1 activity in the presence of 1 mM ATP. The innovative approach involves mapping the binding epitope on ROCK1 using chemical cross-linking to the Activation Loop, which identifies a new class of inhibitory drugs. These peptides have the potential to treat several important diseases, including heart disease, pulmonary hypertension, arterial hypertension, glaucoma management, insulin resistance, kidney disease, hemolytic anemia, stroke, ischemia reperfusion injury, and acute myeloid leukemia. He has 1 patent to his name.
Career Highlights
John W Craft is affiliated with the University of Houston System, where he conducts his research and development work. His contributions to the field of medical science have been recognized for their potential impact on treating serious health conditions.
Collaborations
Some of his notable coworkers include Robert J Schwartz and Hua Zhang, who have collaborated with him on various research projects.
Conclusion
John W Craft's innovative work in developing ROCK inhibitors showcases his commitment to advancing medical science and improving patient outcomes. His contributions are vital in the ongoing fight against significant health challenges.