The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Oct. 01, 2015
University of Houston System, Houston, TX (US);
Robert J. Schwartz, Houston, TX (US);
Hua Zhang, Houston, TX (US);
John W. Craft, Houston, TX (US);
Scott Gilbertson, Houston, TX (US);
Kevin MacKenzie, Houston, TX (US);
Reza Abbasgholizadeh, Houston, TX (US);
Steven Bark, Houston, TX (US);
James M. Briggs, Houston, TX (US);
Robert Fox, Galveston, TX (US);
University of Houston System, Houston, TX (US);
Abstract
The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory polypeptide blocks ROCK1 activity in the presence of 1 mM ATP. The binding epitope on ROCK1 was mapped using chemical cross-linking to the Activation Loop, a novel locus identifying a new class of inhibitory drugs. The peptides described will be useful against a number of important diseases such as heart disease, pulmonary hypertension, arterial hypertension, glaucoma management, insulin resistance, kidney disease, hemolytic anemia, stroke, ischemia reperfusion injury, or acute myeloid leukemia.