John R Frost

Title: Innovations of John R. Frost

Introduction

John R. Frost is an accomplished inventor based in Niagara Falls, NY (US). He has made significant contributions to the field of protein labeling and macrocyclic compounds. With a total of 2 patents, his work has advanced the understanding and application of peptide and protein chemistry.

Latest Patents

One of his latest patents is titled "Methods and compositions for site-specific labeling of peptides and proteins." This patent provides methods for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent that has a reactive amino-thiol group connected to the chemical species intended for covalent linkage. This innovation expands current capabilities in protein functionalization, offering tools for the isolation, detection, characterization, and analysis of proteins in various applications.

Another notable patent is "Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone." This patent describes methods that utilize synthetic molecules and genetically encoded polypeptides to create macrocyclic peptide-containing molecules. These methods enhance the structural diversity of ligand libraries and facilitate functional screening to identify compounds with desired activity properties.

Career Highlights

John R. Frost is affiliated with the University of Rochester, where he continues to contribute to research and innovation in his field. His work has garnered attention for its potential applications in biotechnology and pharmaceuticals.

Collaborations

He has collaborated with notable colleagues, including Rudi Fasan and Jessica M. Smith, further enriching his research endeavors.

Conclusion

John R. Frost's innovative work in peptide and protein chemistry has led to significant advancements in the field. His patents reflect a commitment to enhancing the understanding and application of these important biological molecules.