The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Jan. 20, 2012
Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation
Rudi Fasan, Rochester, NY (US);
John R. Frost, Niagara Falls, NY (US);
Jessica M. Smith, Hamlin, NY (US);
Francesca C. Vitali, Rochester, NY (US);
Rudi Fasan, Rochester, NY (US);
John R. Frost, Niagara Falls, NY (US);
Jessica M. Smith, Hamlin, NY (US);
Francesca C. Vitali, Rochester, NY (US);
University of Rochester, Rochester, NY (US);
Abstract
Methods and compositions are provided that utilize synthetic molecules and genetically encoded polypeptides to generate macrocyclic peptide-containing molecules with a hybrid peptidic/non-peptidic backbone. Also provided are nucleic acid molecules, polypeptides, and methods for generating libraries of macrocyclic peptide-containing molecules with a hybrid peptidic/non-peptidic backbone. These methods can be used to increase the structural diversity of ligand libraries as well as facilitate the functional screening of these libraries to identify compound(s) with desired activity properties.