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Years Active: 2000
Title: John O'Bryan: Innovator in Shc Protein Research
Introduction
John O'Bryan is a notable inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of molecular biology, particularly in the study of Shc proteins. His work has implications for understanding signaling pathways in the nervous system.
Latest Patents
O'Bryan holds a patent for Shc proteins, which are characterized by several distinct features. The protein contains a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain. It is predominantly expressed in the adult brain and binds through its SH2 domain to proteins with a specific consensus sequence. Additionally, it associates through its PTB domain with proteins containing another consensus sequence. The Shc proteins play a crucial role in mediating signaling from tyrosine kinases in the nervous system.
Career Highlights
Throughout his career, John O'Bryan has worked with prestigious institutions such as Mount Sinai Hospital Corporation and the University of North Carolina at Chapel Hill. His research has contributed to advancements in understanding cellular signaling mechanisms.
Collaborations
O'Bryan has collaborated with esteemed colleagues, including Channing J Der and Anthony J Pawson. These partnerships have furthered research in the field and enhanced the impact of his work.
Conclusion
John O'Bryan's innovative research on Shc proteins has made a significant impact in the field of molecular biology. His contributions continue to influence our understanding of signaling pathways in the nervous system.