The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2000
Filed:
Feb. 28, 1997
Channing Der, Chapel Hill, NC (US);
John O'Bryan, Chapel Hill, NC (US);
Anthony Pawson, Toronto, CA;
Mount Sinai Hospital Corporation, Toronto, CA;
University of North Carolina at Chapel Hill, , NC (US);
Abstract
A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.