Company Filing History:
Years Active: 2021
Title: John Joseph Nicols: Innovator in Engineered Phenylalanine Ammonia Lyase Polypeptides
Introduction
John Joseph Nicols is a notable inventor based in Redwood City, CA (US). He has made significant contributions to the field of biochemistry, particularly through his work on engineered phenylalanine ammonia lyase polypeptides. His innovative approach has the potential to impact both therapeutic and industrial applications.
Latest Patents
John Joseph Nicols holds 1 patent for his invention titled "Engineered Phenylalanine Ammonia Lyase Polypeptides." This patent provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding these engineered polypeptides. The engineered PAL polypeptides are optimized to enhance catalytic activity, reduce sensitivity to proteolysis, and increase tolerance to storage at elevated temperatures. Additionally, these polypeptides contain fewer phenylalanine residues than their wild-type counterparts. The invention also outlines methods for utilizing these compositions for therapeutic and industrial purposes.
Career Highlights
John Joseph Nicols has established himself as a key figure in his field through his work at Codexis, Inc. His research and innovations have contributed to advancements in enzyme engineering and biotechnology.
Collaborations
Throughout his career, Nicols has collaborated with notable colleagues, including Chinping Chng and William Casey Hallows. These partnerships have fostered a collaborative environment that enhances the development of innovative solutions in biochemistry.
Conclusion
John Joseph Nicols is a distinguished inventor whose work on engineered phenylalanine ammonia lyase polypeptides exemplifies the intersection of innovation and practical application. His contributions continue to influence the fields of biochemistry and biotechnology.