The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Feb. 12, 2018
Codexis, Inc., Redwood City, CA (US);
Chinping Chng, Menlo Park, CA (US);
William Casey Hallows, San Francisco, CA (US);
Nicholas J. Agard, San Francisco, CA (US);
Oscar Alvizo, Fremont, CA (US);
Nikki Dellas, Mountain View, CA (US);
Gjalt W. Huisman, Redwood City, CA (US);
John Joseph Nicols, Redwood City, CA (US);
Codexis, Inc., Redwood City, CA (US);
Abstract
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis and increased tolerance to storage at elevated temperatures. In some embodiments, the engineered PAL polypeptides contain fewer phenylalanine residues than wild-type PAL polypeptides. The present invention also provides methods for the use of the compositions comprising the engineered PAL polypeptides for therapeutic and industrial purposes.