John J Usher

Title: Innovations and Impact of Inventor John J. Usher

Introduction

John J. Usher is a notable inventor based in East Syracuse, NY, renowned for his contributions to the field of chemistry and pharmaceuticals. With a portfolio of 10 patents, Usher has demonstrated a commitment to innovation, particularly in the development of novel compounds and processes that facilitate advancements in various industries.

Latest Patents

Usher's latest patents showcase his expertise in chemical compounds that serve as important tools in biochemistry. One such patent, focused on Alkyl and aryl-thiotrifluoroacetates, presents new protecting agents useful for amino or hydroxy functional groups. This invention aids in the formation of amide bonds in peptides and proteins, which are significant for creating screening agents, pharmaceuticals, and cosmetics. The process described involves treating C-Calkylthiol or arylthiol with trifluoroacetic anhydride (TFAA) using an organic base such as pyridine and a solvent like dichloromethane (DCM), catalyzed by dimethylaminopyridine (DMAP). Additionally, the method for protecting primary or secondary amino and hydroxyl groups further illustrates his inventive capabilities.

Another significant patent highlights Usher's work on D-hydantoinase derived from Ochrobactrum anthropi. This enzyme enantio-selectively hydrolyzes D-hydantoins into corresponding D-N-carbamoyl-amino acids, a breakthrough that can enhance the production of amino acids within the pharmaceutical industry. This patent also encompasses the nucleic acids encoding the enzyme and the necessary expression vectors or host cells for its production.

Career Highlights

Throughout his career, John J. Usher has been an integral part of Bristol-Myers Squibb Company, where he has driven innovation forward. His role in the company has allowed him to merge scientific research with practical applications, creating significant value in drug development and other chemical processes. His work reflects a deep understanding of both theoretical principles and practical methodologies in chemistry.

Collaborations

Usher's success is further enhanced by his collaborations with notable coworkers such as Guna Romancik and Michael Politino. Working alongside these talented individuals has undoubtedly contributed to the success of their projects and inventions, fostering an environment of teamwork and shared knowledge that is paramount in innovation.

Conclusion

In conclusion, John J. Usher's innovations in chemistry and pharmaceuticals exemplify the role of inventors in driving progress and shaping future technologies. His latest patents not only contribute to academic knowledge but also hold significant potential for practical applications in various industries. As a member of Bristol-Myers Squibb and with the collaborative effort of his colleagues, Usher continues to pave the way for new developments in the field.