The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 1996
Filed:
Feb. 03, 1994
Applicant:
Inventors:
John J Usher, East Syracuse, NY (US);
Guna Romancik, East Syracuse, NY (US);
Michael Politino, Fayetteville, NY (US);
David A Lowe, Fayetteville, NY (US);
Assignee:
Bristol-Myers Squibb Company, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12N / ;
U.S. Cl.
CPC ...
435 47 ; 435 48 ; 435 49 ; 435 50 ; 435 51 ; 435196 ; 435197 ; 435198 ; 435839 ; 435911 ; 435917 ;
Abstract
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.