Company Filing History:
2 out of 310 
1 out of 3,381 
1 out of 455 Years Active: 1994-2010
Title: John J McGuire: Innovator in Antifolate Transport and Metabolism
Introduction
John J McGuire is a notable inventor based in Kenmore, NY (US). He has made significant contributions to the field of medical research, particularly in the area of antifolate transport and metabolism. With a total of 2 patents, McGuire's work has the potential to impact the treatment of various neoplastic diseases.
Latest Patents
One of McGuire's latest patents is titled "5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism." This invention provides a method for increasing the efficacy of antifolates that act via inhibition of dihydrofolate reductase (DHFR). The method involves the administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base alongside the antifolate, ensuring that targeted cells are exposed to both simultaneously. This approach results in an increased influx of the antifolate, enhancing its effectiveness. For methotrexate (MTX), the accumulation of more biologically active polyglutamate forms is also potentiated, mediated by an effect on the reduced folate carrier (RFC).
Another significant patent is related to "Difluoroglutamic acid conjugates with folates and anti-folates." This invention pertains to certain conjugates of folates and antifolates with difluoroglutamic acid, which are useful in treating patients suffering from various neoplastic diseases, including leukemia, melanomas, carcinomas, sarcomas, and mixed neoplasias.
Career Highlights
Throughout his career, John J McGuire has worked with reputable organizations such as Health Research, Inc. and the University of Michigan. His work in these institutions has allowed him to further his research and contribute to advancements in medical science.
Collaborations
McGuire has collaborated with notable individuals in his field, including Philippe Bey and James K Coward. These collaborations have likely enriched his research and led to innovative solutions in antifolate transport and metabolism.
Conclusion
John J McGuire is a distinguished inventor whose work in antifolate transport and metabolism has the potential to significantly impact cancer treatment. His patents reflect a commitment to advancing medical research and improving patient