Company Filing History:
7 out of 115 
1 out of 3,186 
Years Active: 1986-2002
Title: John J Kearns: Innovator in Lipid Complexes for Drug Delivery
Introduction
John J Kearns is an accomplished inventor based in Princeton, NJ, known for his significant contributions to the field of drug delivery systems. With a total of eight patents to his name, Kearns has focused on developing low-toxicity drug-lipid complexes, making strides in improving the administration of toxic hydrophobic drugs.
Latest Patents
Among his latest patents are innovative methods for preparing low-toxicity drug-lipid complexes that facilitate the delivery of toxic drugs, such as the polyene antibiotic amphotericin B. His work emphasizes the creation of nonliposomal lipid complexes using a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in a 7:3 mole ratio. These high drug:lipid complexes (HDLCs) can be administered to mammals, including humans, for treating infections, offering substantially equivalent or greater efficacy while significantly reducing drug toxicities. Kearns also introduced a novel liposome-loading procedure that enhances the formation of these complexes. Additionally, he detailed a phospholipid composition that improves liposome stability, consisting predominantly of phosphatidylcholine.
Career Highlights
Throughout his career, Kearns has played a pivotal role in advancing drug formulation techniques. He has worked with reputable organizations such as the Liposome Company and Air Products and Chemicals, where he has leveraged his expertise to develop innovative solutions for drug delivery challenges.
Collaborations
Kearns has collaborated with noted professionals in the field of biotechnology, including Paul A Tremblay and Andrew S Janoff. These collaborations have further propelled his work and innovation in lipid-based drug delivery systems.
Conclusion
John J Kearns' contributions to improving drug delivery through lipid complexes have marked him as a significant inventor in medical biotechnology. His patents not only demonstrate his innovative spirit but also offer practical solutions to enhance patient safety and treatment efficacy.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.