The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 1997
Filed:
Apr. 28, 1995
Andrew S Janoff, Yardley, PA (US);
Lawrence Boni, Monmouth Junction, NJ (US);
Thomas D Madden, Vancouver, CA;
Pieter R Cullis, Vancouver, CA;
Robert P Lenk, Lambertville, NJ (US);
John J Kearns, Princeton, NJ (US);
Anthony G Durning, Yardley, PA (US);
Robert Klimchak, Flemington, NJ (US);
Joel Portnoff, Richboro, PA (US);
The Liposome Company, Inc., Princeton, NJ (US);
Abstract
Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.