Anthony G Durning

Title: Innovations by Anthony G Durning

Introduction

Anthony G Durning is a notable inventor based in Yardley, PA (US), recognized for his contributions to the field of drug delivery systems. He holds a total of four patents, showcasing his innovative approach to addressing challenges in pharmaceutical formulations.

Latest Patents

Durning's latest patents include methods for preparing low-toxicity drug-lipid complexes. These methods and compositions focus on nonliposomal lipid complexes that associate with toxic hydrophobic drugs, such as the polyene antibiotic amphotericin B. The lipid compositions are primarily a combination of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in a 7:3 mole ratio. The lipid complexes contain a bioactive agent and can be produced through various procedures at high drug-to-lipid ratios. These high drug-to-lipid complexes (HDLCs) can be administered to mammals, including humans, for treating infections, offering comparable or enhanced efficacy and reduced drug toxicities compared to the drugs in their free form. Additionally, Durning has developed a novel liposome-loading procedure that can be utilized in forming HDLCs. Another significant patent involves a method for size separation of particles using tangential flow filtration. This technique allows for the size separation of particles, such as liposomes and lipid particles, through a tangential flow filtration device with any desired pore size.

Career Highlights

Durning's career is marked by his work at The Liposome Company, Inc., where he has made significant advancements in drug delivery technologies. His innovative methods have the potential to revolutionize how certain medications are administered, particularly those with high toxicity profiles.

Collaborations

Durning has collaborated with notable colleagues, including Robert P Lenk and Robert J Klimchak, contributing to the advancement of research and development in the pharmaceutical field.

Conclusion

Anthony G Durning's innovative work in drug-lipid complexes and particle size separation highlights his significant contributions to pharmaceutical science. His patents reflect a commitment to improving drug delivery systems, ultimately benefiting patient care and treatment outcomes.