John J Buckley

Title: Innovations by John J Buckley

Introduction

John J Buckley is a notable inventor based in O'Fallon, MO (US). He has made significant contributions to the field of biotechnology, particularly in the development of growth hormones and their antagonists. With a total of 2 patents, Buckley's work has had a considerable impact on medical science.

Latest Patents

Buckley's latest patents include a method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities. This invention focuses on recombinant methods for producing a desired polypeptide, specifically targeting the reduction of isoform impurities in growth hormone and its antagonist, such as pegvisomant. The methods aim to decrease the trisulfide and des-phe isoform impurities, enhancing the quality of the polypeptide products. Another significant patent is the process for decreasing aggregate levels of pegylated protein, which also utilizes recombinant methods to yield a polypeptide product with reduced aggregate levels.

Career Highlights

John J Buckley is currently associated with Pfizer Corporation, a leading global pharmaceutical company. His work at Pfizer has allowed him to contribute to groundbreaking research and development in the field of biopharmaceuticals.

Collaborations

Throughout his career, Buckley has collaborated with esteemed colleagues, including Denis M Boyle and Gary V Johnson. These partnerships have fostered innovation and have been instrumental in advancing their shared goals in biotechnology.

Conclusion

John J Buckley is a distinguished inventor whose contributions to the field of biotechnology have led to significant advancements in the preparation of growth hormones and their antagonists. His work continues to influence the medical community and improve therapeutic options for patients.