John G Doench

Title: Innovations of John G. Doench

Introduction

John G. Doench is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of functional genomics, particularly through his work with CRISPR-Cas systems. With a total of 3 patents, Doench has been at the forefront of innovative research that has the potential to transform genetic engineering.

Latest Patents

One of his latest patents is titled "Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof." This invention focuses on libraries, compositions, methods, applications, kits, and screens used in functional genomics that emphasize gene function in a cell. It involves vector systems related to CRISPR-Cas systems and provides methods for directing CRISPR complex formation in eukaryotic cells.

Another notable patent is "CRISPR CPF1 direct repeat variants." This invention relates to engineered Cpf1 polynucleotides that can direct the activity of a CRISPR protein to multiple targets using a single crRNA. The methods developed can target sequences in various eukaryotic cells, including human and nonhuman cells, and are aimed at developing CRISPR-Cas system-based therapies.

Career Highlights

John G. Doench has worked with prestigious institutions such as the Broad Institute, Inc. and the Massachusetts Institute of Technology. His research has significantly advanced the understanding and application of CRISPR technology in functional genomics.

Collaborations

Throughout his career, Doench has collaborated with notable scientists, including Feng Zhang and Ophir Shalem. These collaborations have further enhanced the impact of his work in the field of genetic research.

Conclusion

John G. Doench is a key figure in the realm of functional genomics, with a focus on CRISPR technology. His innovative patents and collaborations have paved the way for advancements in genetic engineering and therapeutic applications.